NA Selank Amidate (30mg vials)

Description

N-Acetyl Selank Amidate is a modified form of Selank, a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) based on the immunomodulatory peptide tuftsin, with N-terminal acetylation and C-terminal amidation. Peptide Partners supplies it in 30mg vials for laboratory research into GABAergic signaling and neurotransmission gene expression.

N-Acetyl Selank Amidate specifications

Product Format	30mg vials
Vial Size	30mg
Vial Capacity	3 mL
Box Combinations	60mg, 150mg, 300mg, 600mg
Multi-vial Purity	99.94%
Purity Screening	PASSED
Independently Tested	YES

Published research on N-Acetyl Selank Amidate

The summaries below describe peer-reviewed literature for educational and reference purposes only. They do not describe uses of this product, which is sold for laboratory research only.

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

Authors: Anastasiya Volkova, Maria Shadrina, Timur Kolomin, Lyudmila Andreeva, Svetlana Limborska, Nikolay Myasoedov, Petr Slominsky
Published: Frontiers in Pharmacology, 2016 Feb 18;7:31
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC4757669/

Researchers used a custom RT2 Profiler PCR array to measure expression of 84 neurotransmission-related genes in the rat frontal cortex 1 and 3 hours after Selank or GABA administration, reporting changes in GABA-receptor subunit and dopamine-receptor genes and a correlation between the two compounds’ expression profiles.

GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells

Authors: Elena Filatova, Anastasiya Kasian, Timur Kolomin, Ekaterina Rybalkina, Anelya Alieva, Lyudmila Andreeva, Svetlana Limborska, Nikolay Myasoedov, Galina Pavlova, Petr Slominsky, Maria Shadrina
Published: Frontiers in Pharmacology, 28 February 2017, Volume 8, Article 89
Source: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fph

In the human neuroblastoma line IMR-32, qPCR arrays measured 84 neurotransmission genes after one-hour exposure to Selank, GABA, olanzapine or their combinations. Selank alone did not change mRNA levels, but altered the expression changes produced by GABA and by olanzapine.

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity

Authors: Tatiana V. Vyunova, Lioudmila Andreeva, Konstantin Shevchenko, Nikolay Myasoedov
Published: Protein and Peptide Letters, Volume 25, Number 10, 2018, pp. 914-923(10)
Source: https://www.ingentaconnect.com/content/ben/ppl/2018/00000025/00000010/

Radioligand binding assays with [³H]GABA on isolated brain-cell membranes showed that Selank modulated GABA binding in a concentration-dependent, allosteric manner and altered the binding effects of diazepam and olanzapine, suggesting partially overlapping but distinct binding sites.

Storage and handling

N-Acetyl Selank Amidate is supplied for laboratory use. Store unopened vials cold and protected from light, and follow the storage notes on the vial label. Handle only in an appropriate laboratory setting by qualified personnel.

Research use only

This product is sold solely for in-vitro research and laboratory experimentation. It is not a drug, food, supplement or cosmetic, and is not for human or veterinary use. Information on this page is provided for educational purposes only. Purchasers must be qualified research professionals; see our Terms and Conditions.

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