Thymosin Alpha-1 (TA1, 10mg vials)

Description

Thymosin Alpha-1 (Tα1) is a 28-amino-acid acetylated peptide originally isolated from thymic tissue. Peptide Partners supplies Thymosin Alpha-1 in 10mg vials for laboratory research into immune-cell signaling, including Toll-like receptor pathways and T-cell and macrophage activity.

Thymosin Alpha-1 specifications

Product Format	10mg vials
Vial Size	10mg
Vial Capacity	3 mL
Box Combinations	20mg, 50mg, 100mg
Multi-vial Purity	99.95%
Heavy Metals Screening	PASSED
Purity Screening	PASSED
Independently Tested	YES

Published research on Thymosin Alpha-1

The summaries below describe peer-reviewed literature for educational and reference purposes only. They do not describe uses of this product, which is sold for laboratory research only.

Thymosin Alpha 1 Mitigates Cytokine Storm in Blood Cells From Coronavirus Disease 2019 Patients

Authors: Claudia Matteucci, Antonella Minutolo, Emanuela Balestrieri, Vita Petrone, Marialaura Fanelli, Vincenzo Malagnino, Marco Ianetta, Alessandro Giovinazzo, Filippo Barreca, Silvia Di Cesare, Patrizia De Marco, Martino Tony Miele, Nicola Toschi, Antonio Mastino, Paola Sinibaldi Vallebona, Sergio Bernardini, Paola Rogliani, Loredana Sarmati, Massimo Andreoni, Sandro Grelli, Enrico Garaci
Published: Open Forum Infectious Diseases, Volume 8, Issue 1, January 2021, ofaa588
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC7798699/

Researchers analyzed blood cells collected from individuals with COVID-19 and exposed them to Tα1 ex vivo. Gene-expression and pathway analysis showed changes in cytokine-signaling genes, CD8+ T-cell activation markers and CD38 expression, with Tα1 acting through TLR3, TLR4 and TLR9 pathways and downstream IRF3 and NF-κB signaling.

Thymosin α1 Activates Complement Receptor-Mediated Phagocytosis in Human Monocyte-Derived Macrophages

Authors: Annalucia Serafino, Fabrizio Pica, Francesca Andreola, Roberta Gaziano, Nadia Moroni, Gianluca Moroni, Manuela Zonfrillo, Pasquale Pierimarchi, Paola Sinibaldi-Vallebona, Enrico Garaci
Published: Journal of Innate Immunity, 2014; 6(1):72–88
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC6741600/

Human monocyte-derived macrophages exposed to Tα1 in vitro showed increased uptake of beads, zymosan particles and Aspergillus niger conidia through a complement-receptor-mediated mechanism requiring microtubules and protein kinase C, while transcription of TNFα and IL-6 remained low.

Thymosin Alpha 1 Alleviates Inflammation and Prevents Infection in Patients with Severe Acute Pancreatitis Through Immune Regulation: A Systematic Review and Meta-Analysis

Authors: Ye Tian, Jie Yao, Yulong Ma, Pengfei Zhang, Xinyi Zhou, Wenlong Xie, Wei Tang
Published: Frontiers in Immunology, May 28, 2025; doi: 10.3389/fimmu.2025.1571456
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC12208829/

This systematic review and meta-analysis pooled five randomized controlled trials (706 participants) evaluating Tα1 in severe acute pancreatitis, analyzing immune-cell ratios (CD4+, CD4+/CD8+), C-reactive protein, infection incidence and APACHE II scores across the included studies.

Storage and handling

Thymosin Alpha-1 is supplied for laboratory use. Store unopened vials cold and protected from light, and follow the storage notes on the vial label. Handle only in an appropriate laboratory setting by qualified personnel.

Research use only

This product is sold solely for in-vitro research and laboratory experimentation. It is not a drug, food, supplement or cosmetic, and is not for human or veterinary use. Information on this page is provided for educational purposes only. Purchasers must be qualified research professionals; see our Terms and Conditions.

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