VIP (10mg vials)

Description

VIP (vasoactive intestinal peptide) is a 28-amino-acid neuropeptide of the secretin/glucagon family. Peptide Partners supplies VIP as a lyophilized powder in 10mg vials for in-vitro and laboratory research into neuropeptide receptor signaling (VPAC1, VPAC2) and related cellular pathways.

VIP specifications

Product Format	10mg vials
Vial Size	10mg
Vial Capacity	3 mL
Box Combinations	20mg, 50mg, 100mg, 200mg
Multi-vial Purity	99.42%
Endotoxin Screening	PASSED
Purity Screening	PASSED
Independently Tested	YES

Published research on VIP

The summaries below describe peer-reviewed literature for educational and reference purposes only. They do not describe uses of this product, which is sold for laboratory research only.

Vasoactive Intestinal Peptide (VIP) in COVID-19 Therapy—Shedding of ACE2 and TMPRSS2 via ADAM10

Authors: Charlotte Gutzler, Kerstin Höhne, Daniele Bani, Gian Kayser, Sebastian Fähndrich, Michael Ambros, Martin J Hug, Siegbert Rieg, Valeria Falcone, Joachim Müller-Quernheim, Gernot Zissel, Björn C Frye
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC11942504/

In cultured cells, VIP exposure reduced transcription and surface expression of ACE2 and TMPRSS2 and induced ADAM10-dependent shedding of both proteins; the ADAM10 inhibitor aderbasib blocked this shedding. Cells exposed to VIP also showed lower entry of a SARS-CoV-2 pseudovirus in this assay.

Vasoactive intestinal peptide produces long-lasting changes in neural activity in the suprachiasmatic nucleus

Authors: Takashi Kudo, Yu Tahara, Karen L Gamble, Douglas G McMahon, Gene D Block, Christopher S Colwell
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC4073931/

Using mouse brain-slice cultures, researchers recorded a sustained increase in suprachiasmatic nucleus (SCN) neuronal firing after VIP application. The response depended on the VIPR2 receptor, PKA and Epac signaling, the clock protein PER1, and Kv3 potassium channels.

Vasoactive intestinal peptide promotes secretory differentiation and mitigates radiation-induced intestinal injury

Authors: Tatiana Agibalova, Anneke Hempel, H Carlo Maurer, Mohab Ragab, Anastasia Ermolova, Jessica Wieland, Caroline Waldherr Ávila de Melo, Fabian Heindl, Maximilian Giller, Julius Clemens Fischer, Markus Tschurtschenthaler, Birgit Kohnke-Ertel, Rupert Öllinger, Katja Steiger, Ihsan Ekin Demir, Dieter Saur, Michael Quante, Roland M Schmid, Moritz Middelhoff
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC11462795/

In intestinal organoid and mouse models, VIP influenced proliferation of Lgr5-EGFP+ progenitor cells and shifted epithelial differentiation toward a secretory phenotype through p38 MAPK signaling, including in a radiation-injury model.

Storage and handling

VIP is supplied for laboratory use. Store unopened vials cold and protected from light, and follow the storage notes on the vial label. Handle only in an appropriate laboratory setting by qualified personnel.

Research use only

This product is sold solely for in-vitro research and laboratory experimentation. It is not a drug, food, supplement or cosmetic, and is not for human or veterinary use. Information on this page is provided for educational purposes only. Purchasers must be qualified research professionals; see our Terms and Conditions.

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