Humanin (10mg vials)

Description

Humanin is a 24-amino-acid mitochondrial-derived peptide encoded within the 16S rRNA region of mitochondrial DNA. Peptide Partners supplies Humanin in 10mg vials for laboratory research into mitochondrial-derived peptides, cell signaling and peptide structural biology.

Humanin specifications

Product Format	10mg vials
Vial Size	10mg
Vial Capacity	3 mL
Box Combinations	20mg, 50mg, 100mg
Multi-vial Purity	99.92%
Endotoxin Screening	PASSED
Purity Screening	PASSED
Independently Tested	YES

Published research on Humanin

The summaries below describe peer-reviewed literature for educational and reference purposes only. They do not describe uses of this product, which is sold for laboratory research only.

Humanin activates integrin αV–TGFβ axis and leads to glioblastoma progression

Authors: Cuong P. Ha, Tuyen N. M. Hua, Vu. T. A. Vo, Jiyeon Om, Sangwon Han, Seung-Kuy Cha, Kyu-Sang Park & Yangsik Jeong
Source: https://www.nature.com/articles/s41419-024-06790-8

Combining in-silico, in-vitro and in-vivo approaches, researchers reported that humanin is highly expressed in glioblastoma tissue and binds integrin αVβ8, promoting glioblastoma stem-cell attachment, filopodia formation and migration through activation of the integrin αV–TGFβ signaling axis.

Humanin variants aggregate to produce different fibril morphologies

Authors: Daniel L. Morris, Sarah B. Nyenhuis, James M. Gruschus, David A. Nyenhuis, Rashmi Puja, Jenny E. Hinshaw, Nico Tjandra
Source: https://www.sciencedirect.com/science/article/pii/S0021925825022537

Using transmission electron microscopy and biophysical methods, this study characterized amyloid-like β-sheet fibril formation by humanin and its variants, showing that specific mutations inhibit fibrillization and relating these structural transitions to interactions with BCL-2 family proteins.

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction

Authors: Parameswaran G Sreekumar, Keijiro Ishikawa, Chris Spee, Hemal H Mehta, Junxiang Wan, Kelvin Yen, Pinchas Cohen, Ram Kannan, David R Hinton
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC4811181/

In human retinal pigment epithelial cells, researchers tracked uptake and mitochondrial colocalization of exogenous humanin and measured reactive oxygen species, mitochondrial bioenergetics, mtDNA copy number, mtTFA expression, senescence markers and transepithelial resistance under oxidative stress.

Storage and handling

Humanin is supplied for laboratory use. Store unopened vials cold and protected from light, and follow the storage notes on the vial label. Handle only in an appropriate laboratory setting by qualified personnel.

Research use only

This product is sold solely for in-vitro research and laboratory experimentation. It is not a drug, food, supplement or cosmetic, and is not for human or veterinary use. Information on this page is provided for educational purposes only. Purchasers must be qualified research professionals; see our Terms and Conditions.

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