TB-500 (TB4, 10mg vials)

Description

TB-500 is a synthetic peptide fragment related to thymosin beta-4 (Tβ4), an actin-sequestering protein. Peptide Partners supplies TB-500 in 10mg vials for laboratory research into peptide metabolism, actin dynamics and cell-migration assays.

TB-500 specifications

Product Format	10mg vials
Vial Size	10mg
Vial Capacity	3 mL
Box Combinations	20mg, 50mg, 100mg
Multi-vial Purity	99.76%
Endotoxin Screening	PASSED
Heavy Metals Screening	PASSED
Purity Screening	PASSED
Independently Tested	YES

Published research on TB-500

The summaries below describe peer-reviewed literature for educational and reference purposes only. They do not describe uses of this product, which is sold for laboratory research only.

Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro

Authors: Khandoker Asiqur Rahaman, Anca Raluca Muresan, Hophil Min, Junghyun Son, Hyung-Seop Han, Min-Jung Kang, Oh-Seung Kwon
Source: https://www.sciencedirect.com/science/article/pii/S1570023224000412

Researchers validated a UHPLC-Q-Exactive Orbitrap MS method for TB-500 and its metabolites in human serum, in-vitro enzyme systems and rat urine. Ac-LK was the main metabolite in rats and Ac-LKK a long-term metabolite. In fibroblast scratch assays, only the metabolite Ac-LKKTE differed significantly from control, and no cytotoxicity was observed.

Investigation of in vitro/ex vivo TB-500 metabolism, synthesis of relevant metabolites and detection limits in urine and plasma

Authors: P. Van Eenoo
Source: https://www.wada-ama.org/en/resources/scientific-research/investigatio

Using human liver microsomes, S9 fraction and plasma/serum, this study showed that TB-500 undergoes stepwise C-terminal cleavage while its N-terminal acetylation is protective. Three metabolites and a deuterated internal standard were synthesized, and detection limits of 50–500 pg/mL were established for urine screening.

Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies

Authors: Klaudia Maar, Roland Hetenyi, Szabolcs Maar, Gabor Faskerti, Daniel Hanna, Balint Lippai, Aniko Takatsy, Ildiko Bock-Marquette
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC8228050/

This review summarizes research on thymosin beta-4 in embryonic and adult cardiac tissue models, including in-vitro observations of cardiomyocyte migration and survival and the role of integrin-linked kinase (ILK) and Akt signaling.

Storage and handling

TB-500 is supplied for laboratory use. Store unopened vials cold and protected from light, and follow the storage notes on the vial label. Handle only in an appropriate laboratory setting by qualified personnel.

Research use only

This product is sold solely for in-vitro research and laboratory experimentation. It is not a drug, food, supplement or cosmetic, and is not for human or veterinary use. Information on this page is provided for educational purposes only. Purchasers must be qualified research professionals; see our Terms and Conditions.

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