MOTS-c (40mg vials)

Description

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene. Peptide Partners supplies MOTS-c in 40mg vials for laboratory research into mitochondrial-derived peptides, cellular metabolism and protein-interaction studies.

MOTS-c specifications

Product Format	40mg vials
Vial Size	40mg
Vial Capacity	3 mL
Box Combinations	80mg, 200mg, 400mg
Multi-vial Purity	99.41%
Endotoxin Screening	PASSED
Heavy Metals Screening	PASSED
Purity Screening	PASSED
Independently Tested	YES

Published research on MOTS-c

The summaries below describe peer-reviewed literature for educational and reference purposes only. They do not describe uses of this product, which is sold for laboratory research only.

MOTS-c promotes muscle differentiation in vitro

Authors: Sandra García-Benlloch, Francisco Revert-Ros, Jose Rafael Blesa, Rafael Alis
Source: https://www.sciencedirect.com/science/article/pii/S0196978122001061

In human LHCN-M2 and mouse C2C12 myoblasts, wild-type MOTS-c increased myotube formation and counteracted the IL-6-induced reduction of nuclear myogenin, while a Y8F variant did not. The proposed mechanism involves MOTS-c interacting with STAT3 through its YIFY motif.

The mitochondrial genome-encoded peptide MOTS-c interacts with Bcl-2 to alleviate nonalcoholic steatohepatitis progression

Authors: Huanyu Lu, Linni Fan, Wenli Zhang, Guo Chen, An Xiang, Li Wang, Zifan Lu, Yue Zhai
Source: https://www.sciencedirect.com/science/article/pii/S2211124723015991

Researchers reported that MOTS-c binds the BH3 domain of Bcl-2 and stabilizes it by suppressing ubiquitination. Using a Bcl-2 inhibitor and AAV-mediated knockdown in steatohepatitis models, they examined mitochondrial function, inflammatory and fibrotic markers, and metabolomic profiles.

MOTS-c modulates skeletal muscle function by directly binding and activating CK2

Authors: Hiroshi Kumagai, Su-Jeong Kim, Brendan Miller, et al.
Source: https://www.cell.com/iscience/fulltext/S2589-0042(24)02437-4

In cell-free systems, MOTS-c bound directly to and activated protein kinase CK2, whereas the naturally occurring K14Q variant showed reduced binding and no activation, linking this interaction to MOTS-c’s effects on skeletal-muscle metabolism.

Storage and handling

MOTS-c is supplied for laboratory use. Store unopened vials cold and protected from light, and follow the storage notes on the vial label. Handle only in an appropriate laboratory setting by qualified personnel.

Research use only

This product is sold solely for in-vitro research and laboratory experimentation. It is not a drug, food, supplement or cosmetic, and is not for human or veterinary use. Information on this page is provided for educational purposes only. Purchasers must be qualified research professionals; see our Terms and Conditions.

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