SS-31 (50mg vials)

Description

SS-31 (elamipretide) is a synthetic, cell-permeable tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) that associates with cardiolipin on the inner mitochondrial membrane. Peptide Partners supplies SS-31 in 50mg vials for laboratory research into mitochondrial function and oxidative stress.

SS-31 specifications

Product Format	50mg vials
Vial Size	50mg
Vial Capacity	3 mL
Box Combinations	100mg, 250mg, 500mg
Multi-vial Purity	99.66%
Endotoxin Screening	PASSED
Heavy Metals Screening	PASSED
Sterility Screening	PENDING
Independently Tested	YES

Published research on SS-31

The summaries below describe peer-reviewed literature for educational and reference purposes only. They do not describe uses of this product, which is sold for laboratory research only.

SS-31 protect retinal pigment epithelial cells from H2O2-induced cell injury by reducing apoptosis

Authors: Jie Bai, Yumei Yang, Dingting Wu, Fan Yang
Source: https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13484

In ARPE-19 human retinal pigment epithelial cells, pre-exposure to SS-31 was associated with higher cell viability and lower oxidative damage and apoptosis after hydrogen-peroxide challenge, alongside increased HO-1, Trx-1 and Nrf-2 expression and a shift in the Bax/Bcl-2 ratio.

SS-31 inhibits the inflammatory response by increasing ATG5 and promoting autophagy in lipopolysaccharide-stimulated HepG2 cells

Authors: Yunan Mo, Songyun Deng, Yuhang Ai, Wenchao Li
Source: https://www.sciencedirect.com/science/article/pii/S0006291X24004236

In lipopolysaccharide-stimulated HepG2 cells, SS-31 increased ATG5 levels and autophagic flux, including autophagosome and autolysosome formation. Knocking down ATG5 reduced SS-31’s effect on inflammatory markers in this cell model.

Mitochondrial protein interaction landscape of SS-31

Authors: Juan D. Chavez, Xiaoting Tang, Matthew D. Campbell, Gustavo Reyes, Philip A. Kramer, Rudy Stuppard, Andrew Keller, Huiliang Zhang, Peter S. Rabinovitch, David J. Marcinek, and James E. Bruce
Source: https://www.pnas.org/doi/10.1073/pnas.2002250117

Using chemical cross-linking with mass spectrometry, researchers mapped mitochondrial proteins that interact with SS-31 (elamipretide). The interactors, all known cardiolipin-binding proteins, fell into oxidative-phosphorylation and 2-oxoglutarate metabolic groups.

Storage and handling

SS-31 is supplied for laboratory use. Store unopened vials cold and protected from light, and follow the storage notes on the vial label. Handle only in an appropriate laboratory setting by qualified personnel.

Research use only

This product is sold solely for in-vitro research and laboratory experimentation. It is not a drug, food, supplement or cosmetic, and is not for human or veterinary use. Information on this page is provided for educational purposes only. Purchasers must be qualified research professionals; see our Terms and Conditions.

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