GLP-1 Semaglutide (10mg vials)

Description

Semaglutide is a synthetic GLP-1 receptor agonist peptide with an Aib substitution and a C18 fatty-diacid side chain that promotes albumin binding. Peptide Partners supplies Semaglutide in 10mg vials for in-vitro and laboratory research into GLP-1 receptor signaling in cell models.

GLP-1 Semaglutide specifications

Product Format	10mg vials
Vial Size	10mg
Vial Capacity	3 mL
Box Combinations	50mg, 100mg, 150mg, 200mg
Multi-vial Purity	99.82%
Endotoxin Screening	PASSED
Heavy Metals Screening	PASSED
Purity Screening	PASSED
Doubly Validated	YES
Independently Tested	YES

Published research on GLP-1 Semaglutide

The summaries below describe peer-reviewed literature for educational and reference purposes only. They do not describe uses of this product, which is sold for laboratory research only.

Semaglutide promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells through activation of the Wnt/LRP5/β-catenin signaling pathway

Authors: Yawei Tian, Huiming Liu, Xiaoxue Bao, Yukun Li
Source: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fph

In bone-derived mesenchymal stem cells, researchers measured proliferation, alkaline phosphatase activity, mineralization and the osteogenic markers OCN and RUNX2 after semaglutide exposure. RNA sequencing pointed to Wnt/LRP5/β-catenin signaling, which was tested with the inhibitor DKK1 and the activator LiCl.

The effect of Semaglutide on mitochondrial function and insulin sensitivity in a myotube model of insulin resistance

Authors: Emmalie R. Spry, Kipton B. Travis, Kayla J. Ragland, Alexa J. Klein, John M. Zimmerman, Roger A. Vaughan
Source: https://www.sciencedirect.com/science/article/abs/pii/S030372072500180

In an in-vitro C2C12 myotube model of insulin resistance, semaglutide did not change the pAkt:Akt ratio but was associated with higher expression of PGC-1α and TFAM, greater mitochondrial content and density, and increased maximal mitochondrial respiration.

Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apotosis

Authors: Yan-fang Chang, Di Zhang, Wei-min Hu, Dong-xing Liu, Lin Li
Source: https://www.sciencedirect.com/science/article/abs/pii/S096758682031533

In SH-SY5Y cells exposed to amyloid-β 25-35, researchers measured cell viability, autophagy markers (LC3-II, Atg7, Beclin-1, p62) and the Bcl-2/Bax ratio in the presence of semaglutide.

Storage and handling

GLP-1 Semaglutide is supplied for laboratory use. Store unopened vials cold and protected from light, and follow the storage notes on the vial label. Handle only in an appropriate laboratory setting by qualified personnel.

Research use only

This product is sold solely for in-vitro research and laboratory experimentation. It is not a drug, food, supplement or cosmetic, and is not for human or veterinary use. Information on this page is provided for educational purposes only. Purchasers must be qualified research professionals; see our Terms and Conditions.

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