Cagrilintide (10mg vials)

Description

Cagrilintide is a synthetic, lipidated, long-acting analog of the pancreatic hormone amylin that acts at amylin and calcitonin receptors. Peptide Partners supplies Cagrilintide in 10mg vials for laboratory research into amylin- and calcitonin-receptor pharmacology and receptor structural biology.

Cagrilintide specifications

Product Format	10mg vials
Vial Size	10mg
Vial Capacity	3 mL
Box Combinations	50mg, 100mg, 150mg, 200mg

Published research on Cagrilintide

The summaries below describe peer-reviewed literature for educational and reference purposes only. They do not describe uses of this product, which is sold for laboratory research only.

Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors

Authors: Jianjun Cao, Matthew J. Belousoff, Rachel M. Johnson, Peter Keov, Zamara Mariam, Giuseppe Deganutti, George Christopoulos, Caroline A. Hick, Steffen Reedtz-Runge, Tine Glendorf, Borja Ballarín-González, Kirsten Raun, Charles Bayly-Jones, Denise Wootten & Patrick M. Sexton
Source: https://www.nature.com/articles/s41467-025-58680-y

Researchers used cryo-electron microscopy and molecular dynamics to compare how cagrilintide and native amylin bind calcitonin and amylin receptors, describing shared binding features and the structural and dynamic differences associated with cagrilintide.

Development of Cagrilintide, a Long-Acting Amylin Analogue

Authors: Thomas Kruse, Jakob Lerche Hansen, Kirsten Dahl, Lauge Schäffer, Ulrich Sensfuss, Christian Poulsen, Morten Schlein, Ann Maria Kruse Hansen, Claus Bekker Jeppesen, Charlotta Dornonville de la Cour, Trine Ryberg Clausen, Eva Johansson, Simone Fulle, Rikke Bjerring Skyggebjerg, Kirsten Raun
Source: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00565

This paper describes the design of cagrilintide from amylin, including the sequence modifications and fatty-acid acylation used to extend its duration of action, and its characterization in cell-based receptor-activation assays.

Does receptor balance matter? – Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models

Authors: A.T. Larsen, K.E. Mohamed, N. Sonne, E. Bredtoft, F. Andersen, M.A. Karsdal, K. Henriksen
Source: https://www.sciencedirect.com/science/article/pii/S0753332222012318

In preclinical models, researchers compared the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336, characterizing their relative receptor potency and balance and their effects on metabolic parameters.

Storage and handling

Cagrilintide is supplied for laboratory use. Store unopened vials cold and protected from light, and follow the storage notes on the vial label. Handle only in an appropriate laboratory setting by qualified personnel.

Research use only

This product is sold solely for in-vitro research and laboratory experimentation. It is not a drug, food, supplement or cosmetic, and is not for human or veterinary use. Information on this page is provided for educational purposes only. Purchasers must be qualified research professionals; see our Terms and Conditions.

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